Dianabol is also capable of interaction with the enzyme aromatase resulting in the possibility of estrogenic side effects. Gynecomastia may become apparent even very early into a cycle, so the user must always ensure that they have the necessary drugs to treat the condition at the earliest possible opportunity. A Selective Estrogen Modulator (SERM) such as Tamoxifen (brand name Nolvadex) is usually used in these instances, perhaps with the addition of an anti-estrogen such as Proviron or Arimidex which will help hinder further estrogenic conversion. (For more information see the article Combating Oestrogens & Progesterone ).
Users on an oral steroid cycle may experience a sudden increase in body weight and muscular development, insomnia, irritability, aggressive combative behavior, puffy face, severe acne, bad breath, a yellowing of the eyes and skin, premature hair loss, hyperactivity, and exaggerated mood swings that include uncontrollable outbursts of anger. Males may also experience testicular shrinkage and can develop female breast tissue on the pectoral muscles. Females may also experience a deeper voice and decreased breast size. Continued use can result in life-threatening situations involving the liver, cardiovascular system, and brain.