Hadol

Haloperidol is a typical butyrophenone type antipsychotic that exhibits high affinity dopamine D 2 receptor antagonism and slow receptor dissociation kinetics. [42] It has effects similar to the phenothiazines . [17] The drug binds preferentially to D 2 and α 1 receptors at low dose (ED 50 = and  mg/kg, respectively), and 5-HT 2 receptors at a higher dose (ED 50 =  mg/kg). Given that antagonism of D 2 receptors is more beneficial on the positive symptoms of schizophrenia and antagonism of 5-HT 2 receptors on the negative symptoms, this characteristic underlies haloperidol's greater effect on delusions, hallucinations and other manifestations of psychosis. [43] Haloperidol's negligible affinity for histamine H 1 receptors and muscarinic M 1 acetylcholine receptors yields an antipsychotic with a lower incidence of sedation, weight gain, and orthostatic hypotension though having higher rates of treatment emergent extrapyramidal symptoms .

There are no well controlled studies with Haldol (haloperidol) in pregnant women. There are reports, however, of cases of limb malformations observed following maternal use of Haldol along with other drugs which have suspected teratogenic potential during the first trimester of pregnancy. Causal relationships were not established in these cases. Since such experience does not exclude the possibility of fetal damage due to Haldol, this drug should be used during pregnancy or in women likely to become pregnant only if the benefit clearly justifies a potential risk to the fetus.

An encephalopathic syndrome (characterized by weakness, lethargy , fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis , elevated serum enzymes, BUN , and fasting blood sugar) followed by irreversible brain damage has occurred in a few patients treated with lithium plus HALDOL. A causal relationship between these events and the concomitant administration of lithium and HALDOL has not been established; however, patients receiving such combined therapy should be monitored closely for early evidence of neurological toxicity and treatment discontinued promptly if such signs appear.

During the British Raj era, Morvi State was one of several princely states governed by the Jadeja dynasty of Rajputs . It was classified as an 11-gun salute state . [3] The Machchhu dam failure or Morbi disaster was a dam-related flood disaster which occurred on 11 August 1979, in India . The Machchu-2 dam , situated on the Machhu river, burst, sending a wall of water through the town of Morbi in the Morbi district of Gujarat , India. Estimates of the number of people killed vary greatly ranging from 1800 to 25000 people.

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During the British Raj era, Morvi State was one of several princely states governed by the Jadeja dynasty of Rajputs . It was classified as an 11-gun salute state . [3] The Machchhu dam failure or Morbi disaster was a dam-related flood disaster which occurred on 11 August 1979, in India . The Machchu-2 dam , situated on the Machhu river, burst, sending a wall of water through the town of Morbi in the Morbi district of Gujarat , India. Estimates of the number of people killed vary greatly ranging from 1800 to 25000 people.

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