Nandralone decanoate

There are possible estrogenic side effects of Nandrolone despite it not being a very estrogenic hormone, at least not directly. Nandrolone does aromatize slightly. Aromatization refers to the conversion of testosterone to estrogen . This takes place when the testosterone hormone interacts with the aromatase enzyme. When the conversion takes place this can cause estrogen levels to go up, which can promote gynecomastia and water retention. High blood pressure can also become an issue if water retention becomes severe. Along with the low level of aromatase activity Nandrolone is also a progestin and has a strong binding affinity for the progesterone receptor. This may stimulate the mammary tissue and enhance the risk of gynecomastia in sensitive individuals.

Combating the estrogenic side effects of Nandrolone can be achieved by the use of anti-estrogen medications, specifically Aromatase Inhibitors (AI’s) such as Anastrozole ( Arimidex ). Selective Estrogen Receptor Modulators (SERM’s) are also sometimes used, such as Tamoxifen ( Nolvadex ). However, AI’s are the proper choice as they will directly reduce serum estrogen levels and SERM’s will not. An AI should be enough to reduce and avoid gynecomastia unless the individual already has existing gynecomastia that could potentially be exasperated.

Important Note: It’s often been said that Nandrolone based gynecomastia is based on increases in prolactin. It is true that 19-nor steroids can increase prolactin, which can also negatively affect libido and erection function. Some men may need to use a dopamine agonist to combat this. However, it is not prolactin that causes 19-nor based gynecomastia but rather the imbalance between estrogen and progesterone. If you merely combat prolactin you may find yourself with the very gynecomastia you tried to avoid.
 

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Decanoic acid acts as a non-competitive AMPA receptor antagonist at therapeutically relevant concentrations, in a voltage- and subunit-dependent manner, and this is sufficient to explain its antiseizure effects. [13] This direct inhibition of excitatory neurotransmission by decanoic acid in the brain contributes to the anticonvulsant effect of the MCT ketogenic diet . [13] Decanoic acid and the AMPA receptor antagonist drug perampanel act at separate sites on the AMPA receptor, and so it is possible that they have a cooperative effect at the AMPA receptor, suggesting that perampanel and the ketogenic diet could be synergistic. [13]

Change in intercourse drive or efficiency; diarrhea; hair loss; headache; hassle sleeping. This listing might not describe all potential uncomfortable side effects. Name your well being care supplier instantly in case you are experiencing any indicators of an allergic response: allergic reactions like pores and skin rash, itching or hives, swelling of the face, lips, or tongue; breast lump; respiratory issues; adjustments in temper, particularly anger, melancholy, or rage; change in voice; darkish urine; enhance in facial hair; irregular menstrual durations; zits, nausea, vomiting; abdomen ache; swelling in ankles or legs; trouble passing urine or change within the quantity of urine; yellowing of the eyes or pores and skin.

Nandralone decanoate

nandralone decanoate

Change in intercourse drive or efficiency; diarrhea; hair loss; headache; hassle sleeping. This listing might not describe all potential uncomfortable side effects. Name your well being care supplier instantly in case you are experiencing any indicators of an allergic response: allergic reactions like pores and skin rash, itching or hives, swelling of the face, lips, or tongue; breast lump; respiratory issues; adjustments in temper, particularly anger, melancholy, or rage; change in voice; darkish urine; enhance in facial hair; irregular menstrual durations; zits, nausea, vomiting; abdomen ache; swelling in ankles or legs; trouble passing urine or change within the quantity of urine; yellowing of the eyes or pores and skin.

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