There are possible estrogenic side effects of Nandrolone despite it not being a very estrogenic hormone, at least not directly. Nandrolone does aromatize slightly. Aromatization refers to the conversion of testosterone to estrogen . This takes place when the testosterone hormone interacts with the aromatase enzyme. When the conversion takes place this can cause estrogen levels to go up, which can promote gynecomastia and water retention. High blood pressure can also become an issue if water retention becomes severe. Along with the low level of aromatase activity Nandrolone is also a progestin and has a strong binding affinity for the progesterone receptor. This may stimulate the mammary tissue and enhance the risk of gynecomastia in sensitive individuals.
Combating the estrogenic side effects of Nandrolone can be achieved by the use of anti-estrogen medications, specifically Aromatase Inhibitors (AI’s) such as Anastrozole ( Arimidex ). Selective Estrogen Receptor Modulators (SERM’s) are also sometimes used, such as Tamoxifen ( Nolvadex ). However, AI’s are the proper choice as they will directly reduce serum estrogen levels and SERM’s will not. An AI should be enough to reduce and avoid gynecomastia unless the individual already has existing gynecomastia that could potentially be exasperated.
Important Note: It’s often been said that Nandrolone based gynecomastia is based on increases in prolactin. It is true that 19-nor steroids can increase prolactin, which can also negatively affect libido and erection function. Some men may need to use a dopamine agonist to combat this. However, it is not prolactin that causes 19-nor based gynecomastia but rather the imbalance between estrogen and progesterone. If you merely combat prolactin you may find yourself with the very gynecomastia you tried to avoid.
This steroid can be used for cutting or for bulking. Bodybuilders often stack it with Testosterone for one of the most common and effective bulking cycles. The durabolin / winstrol stack is also very popular. It is believed that Winstrol helps block the progesterone buildup while the durabolin heIps with the joint issues that some suffer while on Winstrol. The joint relief and healing that durabolin provides is one of the main reasons it has become a very popular steroid with Bodybuilders. Androgen side effects are typically not an issue with NPP (Nandrolone Phenylpropionate) as long as doses are kept within reasonable range.
As far as cutting goes, this is a time period where a lot of people try to avoid Nandrolone. However, for a long time, especially in more recent decades, a lot of serious bodybuilders realize that this is a very important drug to incorporate into cutting stacks. It’s not unheard of for someone to use really small amounts of it for the recovery benefits at 100-200mg injected per week. When cutting, you’re going to experience serious pain and wear and tear, but this compound can really help. But other people tend to use it not because of pain relief, but rather, to maintain the mass they might otherwise lose from cutting. It’s also important to note that during caloric deficits you have during cutting phases, Deca-Durabolin can help maintain those as you stay disciplined and continue to lose weight. The typical period of usage for competitors is that in the first half of prep they’ll drop in some Nandrolone, and then as time goes on, they’ll go for compounds that are more likely to add some hardening properties, that way when it comes to show time, they’ll look really dense and freaky on stage. These are commonly DHT based anabolic steroids. But of course, there are those that put it in also due to the great recovery benefits they can enjoy.