The most common daily dose of Anapolon is 100mg, but even at that dosage side-effects like water-retention, elevated blood pressure, acne, hair loss, blood clotting changes, gynocomastia, liver toxicity and mood swings are very often reported. Using aromatase inhibitors to control estrogen aromatization will be ineffective as this drug does not directly convert into estrogen. It was suggested that oxymetholone can activate the estrogen receptor, similar to, but more profoundly than the estrogenic androgen methandriol. Supplements like Milk Thistle can be taken to help keep liver enzyme levels between safe ranges.
The most obvious benefit that injectable steroids have over their oral cousins is that they are not hepatotoxic. Injectable steroids are safer on the liver and the user does not risk hepatic injury because injectable compounds don’t require specific chemical alterations which allow them to survive passing through the liver without being broken almost entirely down. It’s also worth consider that injectable steroids have a much longer half-life due to the ester attached to the hormone. To get the maximum benefit from oral steroids, most must be administered daily, or sometimes they are spread out throughout the day. The ester present in injectable steroids allows a much more infrequent administration and don’t need to be administered daily. More information about Esters